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It's the top site for IT managers and tech ...Krüppel-like factors (KLFs) are deoxyribonucleic acid–binding transcriptional factors that regulate various pathways that control metabolism and other cellular mechanisms. Various KLF isoforms have been associated with cellular, organ, or systemic metabolism. Altered expression or activation of KLFs has been linked to metabolic …1. Introduction. Kruppel-like factors (KLFs) are a family of zinc finger transcription factors (TF) consisting of 17 members. 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